Signal Transduction Reagents and Kits
Enzo Life Sciences L-JNKi1 (1mg)
This L-stereoisomer is a cell permeable JNK (c-Jun N-terminal kinase) inhibitor. For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter. Neuroprotective agent for stroke. Inhibits the interaction between JNK (JNK-1, -2 and –3) and its substrate with the same IC50 (in vitro IC50 ~ 1µM), but is degraded more readily than the D-stereoisomer, thus requiring higher treatment concentrations in vitro and in vivo. Alternative name: JNK inhibitor 1 (L-stereoisomer), c Jun N terminal kinase peptide inhibitor 1, L stereoisomer. Purity: ≥95% (HPLC). Formulation: Lyophilized. Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences E-64-D, (1mg), CAS Number: 88321-09-9
Calpain and cathepsin inhibitor. Cell-permeable, ethyl ester of E-64-c. The ester is hydrolyzed by intracellular esterases to produce E-64-c. Inhibits calpain and cathepsins B, H, and L. Inhibits degradation of autophagic cargo inside autophagolysosomes. Alternative Name: 2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide. Aloxistatin. Formula: C17H30N2O5. MW: 342.4. CAS Number: 88321-09-9. Purity: ≥98% (HPLC). Appearance: White solid. Solubility: Soluble in 100% ethanol (>10mg/ml) or DMSO (20mg/ml). Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months. Long Term Storage: -20°C
Echelon Biosciences Research Labs APP Gamma Secretase Inhibitor - 5 mg, CAS#: 208255-80-5
APP Gamma Secretase Inhibitor - 5mg , N-[N-(3,5-Difluorophenacetyl)-Ala]-S-phenylglycine t-butyl ester Category/Application: Enzyme Substrates This item is non returnable
Enzo Life Sciences 1-Oleoyl-2-acetyl-sn-glycerol (10mg). CAS: 86390-77-4
In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets. Stimulates formation of actin nucleation sites. Stimulation of pp60c-src phosphorylation in EBV transformed B-cells, 470μM. Alternative name: OAG. Purity: ≥98% (TLC). Solubility: Soluble in DMSO or ethanol. Long Term Storage: -20°C.